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Reynolds Introduces Velo. Share this article:. These amino acids also help with chronic respiratory conditions, fertility and brain health.
Along with two other amino acids — glutamine and glycine — NAC is needed to make and replenish glutathione. Some researchers believe it may even contribute to longevity 1.
Its antioxidant properties are also important for combatting numerous other ailments caused by oxidative stress, such as heart disease, infertility and some psychiatric conditions 2.
It can help prevent side effects of drugs and environmental toxins 3. In fact, doctors regularly give intravenous IV NAC to people with an acetaminophen overdose to prevent or reduce kidney and liver damage 4.
NAC also has applications for other liver diseases due to its antioxidant and anti-inflammatory benefits 5. NAC helps regulate levels of glutamate — the most important neurotransmitter in your brain 6.
While glutamate is required for normal brain action, excess glutamate paired with glutathione depletion can cause brain damage.
This may contribute to mental health conditions, such as bipolar disorder, schizophrenia, obsessive-compulsive disorder OCD and addictive behavior 7 , 8.
For people with bipolar disease and depression, NAC may help decrease symptoms and improve your overall ability to function.
Likewise, an animal study implied that NAC may minimize negative effects of schizophrenia, such as social withdrawal, apathy and reduced attention spans NAC supplements can also help decrease withdrawal symptoms and prevent relapse in cocaine addicts 12 , Additionally, preliminary studies show that NAC may decrease marijuana and nicotine use and cravings 14 , Many of these disorders have limited or currently ineffective treatment options.
NAC may be an effective aid for individuals with these conditions NAC can relieve symptoms of respiratory conditions by acting as an antioxidant and expectorant, loosening mucus in your air passageways.
As an antioxidant, NAC helps replenish glutathione levels in your lungs and reduces inflammation in your bronchial tubes and lung tissue.
People with chronic obstructive pulmonary disease COPD experience long-term oxidative damage and inflammation of lung tissue, which causes airways to constrict — leading to shortness of breath and coughing.
By thinning mucus in your bronchial tubes and boosting glutathione levels, NAC may help decrease the severity and frequency of wheezing, coughing and respiratory attacks In addition to relieving COPD and bronchitis, NAC may improve other lung and respiratory tract conditions like cystic fibrosis, asthma and pulmonary fibrosis, as well as symptoms of nasal and sinus congestion due to allergies or infections The brain neurotransmitter glutamate is involved in a broad range of learning, behavior and memory actions, while the antioxidant glutathione helps reduce oxidative damage to brain cells associated with aging 6.
Because NAC helps regulate glutamate levels and replenish glutathione, it may benefit those with brain and memory ailments 4.
Both oxidative damage to cells and a decrease in antioxidant ability contribute to this disease. NAC supplements appear to improve both dopamine function and disease symptoms such as tremors 4.
While NAC may improve brain health , more human research is needed to make strong conclusions. In almost half of these cases, male infertility is the main contributing factor Many male infertility issues increase when antioxidant levels are insufficient to combat free radical formation in your reproductive system.
The oxidative stress can cause cell death and reduced fertility One condition that contributes to male infertility is varicocele — when veins inside the scrotum become enlarged due to free radical damage.
Surgery is the primary treatment. In one study, 35 men with varicocele were given mg of NAC per day for three months post-surgery.
Another study in men with infertility found that supplementing with mg of NAC and mcg of selenium for 26 weeks improved semen quality Researchers suggested that this combined supplement should be considered as a treatment option for male infertility.
This can lead to damage or destruction of insulin receptors and put you at a higher risk of type 2 diabetes Animal studies show that NAC may stabilize blood sugar by decreasing inflammation in fat cells and thereby improving insulin resistance 31 , When insulin receptors are intact and healthy, they properly remove sugar from your blood, keeping levels within normal limits.
However, keep in mind that human research on NAC is needed to confirm these effects on blood sugar control. Oxidative damage to heart tissue often leads to heart disease, causing strokes, heart attacks and other serious conditions.
NAC may reduce heart disease risk by reducing oxidative damage to tissues in your heart It has also been shown to increase nitric oxide production, which helps veins dilate and improves blood flow.
This expedites blood transit back to your heart and can lower your risk of heart attacks Research on certain diseases associated with NAC and glutathione deficiency suggests that immune function might be improved — and potentially restored — by supplementing with NAC In two studies, supplementing with NAC resulted in a significant increase in immune function — with an almost complete restoration of natural killer cells 36 , 37 , This could potentially reduce the symptoms and lifespan of the illness Similarly, other test-tube studies have linked NAC to cancer cell death and blocked cancer cell replication 41 , Overall, more human studies are needed.
Therefore, be sure to talk to your doctor before taking NAC during cancer treatment There is no specific dietary recommendation for cysteine because your body can produce small amounts.
For your body to make the amino acid cysteine, you need adequate amounts of folate, vitamin B6 and vitamin B These nutrients can be found in beans, lentils, spinach, bananas, salmon and tuna.
While most protein-rich foods, such as chicken, turkey, yogurt, cheese, eggs , sunflower seeds and legumes, contain cysteine, some people choose to supplement with NAC to increase their cysteine intake.
The accepted daily supplement recommendation is —1, mg of NAC 44 , NAC can be administered as an IV or taken orally, as an aerosol spray or in liquid or powder form.
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